The Forest is located about 70 air miles northwest of Phoenix, Arizona, contains approximately 1,237,000 acres, and is composed of two distinct divisions. The eastern portion of the Forest, which forms the headwaters of the Verde River (sections of this river have been designated as a component of the Wild and Scenic River System), is bordered on the north by the Kaibab National Forest, on the east by the Coconino National Forest, and on the south by the Tonto National Forest. The western portion of the Forest, which includes the Bradshaw and Santa Maria mountain ranges, is separated from the eastern portion by a broad patchwork of state, private, and other Federal lands. It forms the southern and western boundaries of the town of Prescott, the first capital of the territory of Arizona.

The forest contains 10 campgrounds, 4 group reservation campgrounds, 7 picnic areas, and 2 group reservation picnic areas. Most of the developed recreation sites are located in the pines with 5 of the campgrounds and two of the picnic areas situated near manmade lakes. Several developed sites offer barrier-free access for users experiencing disabilities.

Nearly 450 miles of scenic trails for hiking, backpacking, horseback riding, or mountain biking are offered on the Prescott National Forest. The forest also contains one National Recreational Trail (Granite Mountain Trail) and one National Historic Study trail (General Crook Trail). The mild climate allows the trails to be enjoyed year-round.